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Risk Factors
May 29, 2024

Adolescent Cannabis Use is Associated with Regional Decreases in Cortical Volume and Greater Decreases in Males than Females

Mona Darvishi of The Ohio State University reported that adolescent cannabis use is associated with regional decreases in cortical volume in 10 of 42 brain regions. -- In two of these regions, the superior frontal gyrus an...
Risk Factors
May 10, 2023

Young Men at Highest Schizophrenia Risk From Cannabis Abuse

Roughly 15% of schizophrenia cases among young males may be preventable by avoiding cannabis use disorder (CUD). Not only does cannabis abuse markedly increase the risk of schizophrenia, its use has transgenerational effec...
Risk Factors
December 7, 2022

Cannabidiol (CBD) does not make cannabis safer

Amir Englund et al reported in Neuropsychopharmacology in A randomised, double-blind, cross-over trial of cannabis with four different CBD:THC ratios that CBD did not protect against the adverse effect of THC. These includ...
Childhood
December 6, 2022

Adolescent Delta-9-tetrahydrocannabinol induces long-term neuronal disturbances in dorsal vs. ventral hippocampus

De Felice et al reported in Neuropsychopharmacology (2022) how adolescent THC exposure in a rodent model can induce significant morphological disturbances and glutamatergic signaling abnormalities in the hippocampus. The d...
Treatments
May 15, 2020

Cannabis Withdrawal Syndrome Occurs in Almost Half of Regular Users

Photo by Thought Catalog on Unsplash -- A recent systematic review and meta-analysis by researcher Anees Bahji and colleagues in the open access medical journal JAMA Network Open describes the symptoms and prevalence of ca...
Risk Factors
April 24, 2020

Cannabis Use in Adolescence Linked to Depression and Suicidality in Young Adulthood

Photo by Louis Hansel @shotsoflouis on Unsplash -- In a meta-analysis published in the journal JAMA Psychiatry in 2019, researcher Gabriella Gobbi and colleagues analyzed findings from 11 studies including a total of 23,31...
Biology
April 21, 2020

In Animal Model, Long-Term THC Exposure Interferes with Cortical Control of the Nucleus Accumbens

Cannabis plant. Photo by Esteban Lopez on Unsplash -- In an article in the journal Biological Psychiatry, researchers Eun-Kyung Hwang and Carl R. Lupica reported that in rats, long-term use of THC (tetrahydrocannabinol) we...
Public Policy
May 8, 2017

National Academy of Sciences, Engineering and Medicine Issues Report on the Health Effects of Cannabis

In early 2017, the National Academy of Sciences, Engineering, and Medicine issued its first comprehensive report on cannabis since 1999. Shifting public opinion over the past few decades has led to 28 states and the Distri...
Childhood
November 9, 2015

Link Between Childhood Trauma and Difficult Course of Bipolar Disorder Clarified

A collaboration between Norwegian and French researchers led by Bruno Etain has clarified the pathway by which childhood trauma is linked to worse outcomes among people with bipolar disorder. The researchers, who presented...